SUBJECT
Title
Biophysical methods to study macromolecular structures
Type of instruction
lecture
Level
master
Faculty
Part of degree program
Credits
2
Recommended in
Semester 2
Typically offered in
Spring semester
Course description
The course covers the basic biophysical techniques used to investigate macromolecular structures: X-ray crystallography, NMR/ESR spectroscopy, mass spectroscopy, electrophoresis, and optical spectroscopy: absorption-, fluorescence-, infrared- and Raman-spectroscopy.
Readings
- Cantor Schimmel: Biophysical Chemistry, Part II. Freeman, 1980 San Francisco.
- Gáspári Zoltán és Perczel András: A fehérjék újrafelvedezett térszerkezete. Biokémia 27:33-40 (2003)
- Wolfgang Paul: Electromagnetic traps for charged and neutral particles. Nobel Lecture, 1989
- John Fenn: Elecytrospray wings for molecular elephants. Nobel Lecture, 2002
- Koichi Tanaka: The origin of macromolecule ionization by laser irradiation. Nobel Lecture, 2002