Chemistry of Organic Fluorine Compounds

Type of instruction




Part of degree program


Recommended in

Semesters 1-4

Typically offered in

Autumn/Spring semester

Course description

History of fluorine compounds. Properties of fluorine and fluorine compounds. Nomenclature and spectroscopy. Effect of fluorine and fluorine containing substituents on reaction rates. Basic methods for the preparation of organofluorine compounds. Selective and exhaustive fluorinations. The role of fluorine in agrochemicals and pharmaceuticals. Fluorine chemistry and ‗performance chemicals‘. Introduction of 18F into PET diagnostics. Basics of fluorous biphasic catalysis and fluorous chemistry. Fluorophilicity, lipophilicity and molecular structure. Use of inorganic and organic fluorine compounds for organic syntheses.



  • Horváth, I. T.; Rábai, J. Science 1994,266,72 ; idem: US Patent 5,463,082, 1995; Chem. Abstr. 1995,123,87349;

  • Horváth, I. T.; et al. J. Am. Chem. Soc. 1998,120, 3133; (4) Curran, D. P., et al. Science1997,275, 823; Curran D. P., et al. Science2001,291,1766.


  • Handbook of Fluorous Chemistry, Eds.: J. A. Gladysz, D. P. Curran, I. T. Horváth; Wiley-VCH, Weinheim, 2004.

  • FLUORINE, the First Hundred Years (1886-1986), Eds.: R. E. Banks, D. W. A. Sharp, J. C. Tatlow; Elsevier Sequoia, Lausannae and New York, 1986.

  • Chemistry of Organic Fluorine Compounds, 2nd ed., M. Hudlicky; Ellis Horwood and Prentice Hall, New York, 1976, 1992. Organofluorine Chemistry

  • Principles and Commercial Applications, Eds.: R. E. Banks, B. E. Smart, J. C. Tatlow; Plenum, New York, 1994 Fluorine Compounds

  • Chemistry and Applications; N. Ishikawa, Y. Kobayashi; Kodansha Scientific, 1979