SUBJECT

Combinatorial Chemistry

lecture

Master

Faculty of Science

Chemistry MSc

2

Semester 2

Spring semester

Combinatorial synthesis strategies (parallel & split–mix). One-bead one-peptide approach. Deconvolution methods. High-throughput synthesis in multimilligram quantities. Synthesis on membrane support. Resins and anchors for solid phase organic synthesis. Diversity- and target-oriented organic syntheses. Analytical methods in combinatorial chemistry. Multi-component reactions. Multi-step solution phase combinatorial synthesis. Experimental techniques in combinatorial fluorous synthesis. Automated solution phase synthesizers. Discovery of new catalysts by combinatorial synthesis. High-throughput screening assays. Combinatorial chemistry in drug discovery.

Compulsory:

• Fenniri H.: Combinatorial Chemistry — A Practical Approach, Oxford Univ. Press, 2000

Suggested:

• Furka Á: Combinatorial chemistry: Principles and Techniques, Internet Edition, 2007.

• Furka Á: History of Combinatorial Chemistry, Drug Development Research,1995,36, 1–12.

• Furka Á, Bennett WD: Combinatorial libraries by portioning and mixing, Comb. Chem.

• High Throughput Screening, 1999,2, 105–122.