Derivatization in Chromatography
Problems in gas and liquid chromatography, which can be solved by derivatization (e.g. improve peak shape, separation and volatility), detector-oriented derivatives for ECD, MSD, etc., and derivatization reactions for different types of compounds, detailed treatment of silylation (silylating agents, stability of Si–O bond, mechanism of silylation), chiral derivatizations, techniques for derivatization (pre-, on and post column, etc.), practical examples (e.g. steroids, drugs, aflatoxins), some related fields, like cyclodextrines in capillar electrophoresis, surface modifications by silylation etc.
C. F. Poole, S. K. Poole: Chromatography today, Elsevier, Amsterdam, 1991, pp. 848-914,
Lecture slides will be provided electronically
Recently published articles (e.g. in Journal of Chromatography A)
Pierce Chromatography Catalog and Handbook, Rockford, 2003, www.piercenet.com
D. R. Knapp: Handbook of Analytical Derivatization Reactions, John Wiley and Sons, 1979