SUBJECT
Structure – Function of Drugs I
lecture
Maste
2
Semester 2
Spring semester
Topics covered by the course: Quality, efficacy and safety aspects of drugs. Toxicology, genotoxicology and reproductive toxicology. Pharmacokinetics and drug-metabolism. Structure – function studies, experimental design. Stability studies. Mechanisms of action. Interaction of drugs and other xenobiotics with the human body. Pharamacokinetics, phases of biotransformation.
Compulsory literature*:
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R. Ng: Drugs-From Discovery to Approval, 3rd Edition Wiley, 2015
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K. Stromgaard, P. Krogsgaard-Larsen and U. Madsen: Textbook of Drug Design and Discovery 4th Edition, CRC Press, 2009
Suggested literature:
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Chi-Jen Lee et al.: Development and Evaluation of Drugs: From Laboratory through Licensure to Market, 2nd Edition, 2003
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G. Thomas: Medicinal Chemistry: An Introduction, 2nd Edition Wiley, 2008
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J. G. Cannon: Pharmacology for Chemists (ACS Professional Reference Book), 2nd Edition, Oxford University Press, 2007
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Drug Design Strategies: Computational Techniques and Applications RSC Drug Discovery Series Editor(s): Lee Banting, Tim Clark, 2012