SUBJECT
From Birth to Pass Away, the Molecular Biology of Pattern Formation II
lecture
master
2
Semesters 1-4
Autumn/Spring semester
Titles and sub-titles on the weeks in the second semester
1 Introduction
Overwiev of topics in the first semester.
The program of the second semester
1-4 The beauty of flowers - pattern formation in plants
The origin of asymmetry - patterning in the early embryogenesis
Latter pattern formation events I. - patterning in vegetative apices
- the formation of tissue zonation and nesting in the root tip
- the formation of shoot architecture
Latter pattern formation events II. - floral patterning
- the genetics of whorl determination
- the control of floral patterning: the determination of meristem type, floral
organs, shape and coloration
The patterning of time - molecular clock mechanisms
- the structure of biological clock mechanisms
- plant clock mechanisms in the determination of flowering time
6-8 Arms, legs, wings - the control of appendage development in vertebrates
The early and late patterning - the "Hox" divide
The structural and functional properties of Hox genes
The definition of the position and type of limb primordium and the formation of the x/y
axes
- the x/y polarization in the limb primordia
- segmentation along the proximo-distal (z) axis - expression fields, morphogen
gradients, and the ZPA and AER organizators
- the Hox-scaling of z-segments
Scaling of a segment - determination of the numbers and types of fingers
- the Shh-Gli3 system
- the role of Hox genes
9-10 Fine tuning and maintenance - finishing works in body pattern formation
Dimensioning - the determination of size
- controlling the balance of cell cycle and apoptosis
- dimension and shape variants in leaves, flowers and wings
Design "without patterning"
Repair mechanisms - the maintenance of patterns
- the role of stem cells
- regulators of pattern formation and the maintenance of stem cell state
11-14 Why dragons do not exist? - perturbations in molecular patterning
Organismic level perturbaions in the function of pattern controlling molecules
Species level perturbations in the control of patterning
- gnoms or the evolution of ontogenesis - EVO-DEVO
- genetic interpretation of (ECO)-EVO-DEVO
The descendance of Hox-genes and the evolution of design
The mecahnisms of speciation - the significance of the quantity and quality of Hox proteins
- the descendance maize fro teozinte
- the appendage evolution in vertebrates
- insect evolution with changes of Ubx
- the "Hox model" of shape evolution in modular segments
The dynamics of speciation - the role of stress factor
- variant generation with Hsp90 inactivation
- the interpretation of gradual and puncuated evolution
"Applied" EVO-DEVO - hopeful monsters
A "brave new world" - concluding remarks
-
Carroll, Grenier, Weatherbee: From DNA to diversity, molecular genetics and the evolution of animal design, second edition, (Blackwell Publishing, 2005),
-
Lecture notes and slides