SUBJECT

The Innate Immunity, Evolution of the Immune System

lecture

master

Faculty of Science

Biology MSc

2

Semesters 1-4

Autumn/Spring semester

1. Cells and humoral elements of innate immunity

2. Evolution of the immune system in invertebrates

3. Evolution of the immune system in vertebrates

4. Structure and function of pattern recognition receptors (PRR); Toll-like receptors (TLR), Mannose- and Scavenger receptors)

5. Development of professional antigen-presenting cells (dendritic cells, macrophages); their characteristic features

6. The role of dendritic cells in initiating adaptive responses; antigen presentation

7. The role of NK cells and granulocytes in innate responses

8. Plasma enzyme-systems of higher vertebrates; mechanism of tissue destruction and remodeling

9. Development and characteristic features of inflammation; features and function of acute-phase reaction

10. The role of the complement system in innate and adaptive responses

11. The structure and function of complement proteins and receptors

12. The central role of complement component C3

13. The interplay between innate and adaptive immunity

• Chapters of Immunobiology, Janeway et al., 6th EditionGarland Science - available through internet, as well

• "The dynamic synapse" Science 298 (2002 October) 769-790

• Matkó J: K+-channels and T-cell synapses: the molecular ground for efficient immunomodulation is shaping up. Trends in Pharmacological Sciences 2003. 24: 385-389.